Major challenges in Drug Delivery

Major Challenges in Drug Delivery Systems are delivery of poorly soluble drugs and bioavailability hurdles for poorly soluble clinical candidates. There are several Novel approaches in the delivery, Overcoming bioavailability hurdles and Rationale formulation design of poorly soluble drugs. Other Major Challenges in Drug Delivery are protein drug delivery, paediatric and geriatric drug delivery.  Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Taking dosage form into consideration makes the event Pharmaceutica 2018 a dosage form meeting.

There is an increasing demand for effective and, ideally, non-invasive drug-delivery methods. This is especially the case for the biopharmaceutical sector, which has experienced an overwhelming growth due to advances in biotechnology. In 2009, over $12 billion were invested in biologics / biotechnology research and development (R&D), representing a 26% share in the total R&D expenditure. A recent report by the Pharmaceutical Research and Manufacturers of America (PhRMA) states that in 2015 there were 901 biological in development, targeting more than 100 diseases.

New classes of pharmaceuticals and biologics (peptides, proteins and DNA-based therapeutics) are fueling the rapid evolution of drug delivery technology. These new drugs typically cannot be effectively delivered by conventional means. Additionally, it has been determined that, for many conventional pharmaceutical therapies, the efficacy may be improved and the side effects reduced if the therapy is administered continuously (although potentially variable rate), rather than through conventional burst release techniques (oral ingestion, injection, etc).

  • • Problems involved and overcoming challenges in the delivery of poorly soluble drugs
  • • Novel approaches in the delivery of poorly soluble drugs
  • • Overcoming bioavailability hurdles for poorly soluble clinical candidates
  • • Rationale formulation design for poorly soluble compounds
  • • Overcoming challenges in protein drug delivery
  • • Challenges in pediatric and geriatric drug delivery
  • • Overcoming addictive nature of drugs

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